Increase hemoglobin level in severe malarial anemia while controlling parasitemia: A mathematical model.

Siewe, Nourridine; Friedman, Avner

Siewe, Nourridine; Friedman, Avner.

Affiliation

Siewe N; National Institute for Mathematical and Biological Synthesis, University of Tennessee, Knoxville, TN 37996, USA. Electronic address: nourridine@aims.ac.za.
Friedman A; Mathematical Biosciences Institute, Ohio State University, Columbus, OH 43210, USA. Electronic address: afriedman@math.osu.edu.

Math Biosci ; 326: 108374, 2020 08.

Article in En | MEDLINE | ID: mdl-32416085

Subject(s)

Anemia/blood; Anemia/drug therapy; Hemoglobins/metabolism; Malaria, Falciparum/blood; Malaria, Falciparum/drug therapy; Models, Biological; Parasitemia/blood; Parasitemia/drug therapy; Anemia/parasitology; Animals; Antimalarials/administration & dosage; Artesunate/administration & dosage; Computer Simulation; Dendritic Cells/immunology; Dendritic Cells/parasitology; Drug Therapy, Combination; Erythrocytes/parasitology; Humans; Intramolecular Oxidoreductases/antagonists & inhibitors; Limonins/administration & dosage; Macrophage Activation; Macrophage Migration-Inhibitory Factors/antagonists & inhibitors; Malaria, Falciparum/parasitology; Mathematical Concepts; Mice; Models, Immunological; Parasitemia/parasitology; Th1 Cells/immunology; Th1 Cells/parasitology

Key words

Artesunate; Epoxyazadiradione; Hemoglobin level; MIF; Parasitemia; Severe malarial anemia

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemoglobins / Malaria, Falciparum / Parasitemia / Anemia / Models, Biological Limits: Animals / Humans Language: En Journal: Math Biosci Year: 2020 Document type: Article

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