Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice.

Loeser, Richard F; Kelley, Kathryn L; Armstrong, Alexandra; Collins, John A; Diekman, Brian O; Carlson, Cathy S

Loeser, Richard F; Kelley, Kathryn L; Armstrong, Alexandra; Collins, John A; Diekman, Brian O; Carlson, Cathy S.

Affiliation

Loeser RF; University of North Carolina School of Medicine, Chapel Hill.
Kelley KL; University of North Carolina School of Medicine, Chapel Hill.
Armstrong A; University of Minnesota College of Veterinary Medicine, St. Paul.
Collins JA; University of North Carolina School of Medicine, Chapel Hill.
Diekman BO; University of North Carolina School of Medicine, Chapel Hill, and North Carolina State University, Raleigh.
Carlson CS; University of Minnesota College of Veterinary Medicine, St. Paul.

Arthritis Rheumatol ; 72(10): 1679-1688, 2020 10.

Article in En | MEDLINE | ID: mdl-32418287

Subject(s)

Aging/metabolism; Cartilage, Articular/metabolism; Cellular Senescence/genetics; Knee Joint/metabolism; Mitogen-Activated Protein Kinase 8/metabolism; Mitogen-Activated Protein Kinase 9/metabolism; Osteoarthritis/metabolism; Animals; Chondrocytes/metabolism; Disease Models, Animal; Matrix Metalloproteinase 13/metabolism; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 8/genetics; Mitogen-Activated Protein Kinase 9/genetics; Osteoarthritis/diagnosis; Osteoarthritis/genetics; Severity of Illness Index

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Aging / Cartilage, Articular / Cellular Senescence / Mitogen-Activated Protein Kinase 8 / Mitogen-Activated Protein Kinase 9 / Knee Joint Limits: Animals Language: En Journal: Arthritis Rheumatol Year: 2020 Document type: Article Country of publication: United States

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