Last Decade of Unconventional Methodologies for the Synthesis of Substituted Benzofurans.
Molecules
; 25(10)2020 May 16.
Article
in En
| MEDLINE
| ID: mdl-32429435
ABSTRACT
This review describes the progress of the last decade on the synthesis of substituted benzofurans, which are useful scaffolds for the synthesis of numerous natural products and pharmaceuticals. In particular, new intramolecular and intermolecular C-C and/or C-O bond-forming processes, with transition-metal catalysis or metal-free are summarized. (1) Introduction. (2) Ring generation via intramolecular cyclization. (2.1) C7a-O bond formation (route a). (2.2) O-C2 bond formation (route b). (2.3) C2-C3 bond formation (route c). (2.4) C3-C3a bond formation (route d). (3) Ring generation via intermolecular cyclization. (3.1) C7a-O and C3-C3a bond formation (route a + d). (3.2) O-C2 and C2-C3 bond formation (route b + c). (3.3) O-C2 and C3-C3a bond formation (route b + d). (4) Benzannulation. (5) Conclusion.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzofurans
/
Biological Products
/
Pharmaceutical Preparations
/
Chemistry Techniques, Synthetic
Limits:
Humans
Language:
En
Journal:
Molecules
Journal subject:
BIOLOGIA
Year:
2020
Document type:
Article
Affiliation country:
Italy