Anti-inflammatory xanthone derivatives from Garcinia delpyana.
J Asian Nat Prod Res
; 23(5): 414-422, 2021 May.
Article
in En
| MEDLINE
| ID: mdl-32432493
ABSTRACT
Two new xanthones delpyxanthone A (1) and delpyxanthone B (3), together with four known ones, gerontoxanthone I (2), α-mangostin (4), cowanin (5) and cowanol (6) were isolated from the stem bark of Garcinia delpyana. The chemical structures of 1-6 were established mainly using nuclear magnetic resonance (NMR) and mass spectrometry (MS). The anti-inflammatory activity of the isolated compounds was evaluated against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells in vitro. Compounds 1-4 showed significant inhibitory activity against the LPS-induced NO production in RAW264.7 cells with IC50 values ranging from 14.5 to 28.2 µM, but the others were inactive. The results suggested that G. delpyana and its constituents might be potential anti-inflammatory agents on RAW 264.7 cells.[Formula see text].
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Garcinia
/
Xanthones
Limits:
Animals
Language:
En
Journal:
J Asian Nat Prod Res
Journal subject:
BOTANICA
/
QUIMICA
Year:
2021
Document type:
Article
Affiliation country:
Vietnam
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM