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A trial comparing continuous positive airway pressure (CPAP) devices in preterm infants.
Backes, Carl H; Cooper, Jennifer N; Notestine, Jennifer L; Alfred, Crystal M; Ball, Molly K; Rivera, Brian K; Lamp, Jane M; Marzec, Laura; Stenger, Michael R; Moallem, Mohannad; Miller, Randy R; Naik, Apurwa; Beer, Lindsey J; Howard, Christopher R; Welty, Stephen E; Peter Richardson, C; Hillman, Noah H; Zupancic, John A F; Stanberry, Larissa I; Hansen, Thomas N; Smith, Charles V.
Affiliation
  • Backes CH; Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Carl.backesjr@nationwidechildrens.org.
  • Cooper JN; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Carl.backesjr@nationwidechildrens.org.
  • Notestine JL; The Heart Center, Nationwide Children's Hospital, Columbus, OH, USA. Carl.backesjr@nationwidechildrens.org.
  • Alfred CM; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Ball MK; Center for Surgical Outcomes, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
  • Rivera BK; Division of Epidemiology, The Ohio State University College of Public Health, Columbus, OH, USA.
  • Lamp JM; Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
  • Marzec L; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Stenger MR; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Moallem M; Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
  • Miller RR; Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
  • Naik A; Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
  • Beer LJ; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Howard CR; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Welty SE; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Peter Richardson C; Department of Pediatrics, Mt. Carmel St. Ann's Hospital, Westerville, OH, USA.
  • Hillman NH; OhioHealth Grant Medical Center, Columbus, OH, USA.
  • Zupancic JAF; Central Ohio Newborn Medicine, Columbus, OH, USA.
  • Stanberry LI; Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Hansen TN; Seattle Children's Research Institute, Seattle Children's Hospital, Seattle, WA, USA.
  • Smith CV; Seattle Children's Research Institute, Seattle Children's Hospital, Seattle, WA, USA.
J Perinatol ; 40(8): 1193-1201, 2020 08.
Article in En | MEDLINE | ID: mdl-32433510
ABSTRACT

OBJECTIVE:

To test the hypothesis that infants born <30 weeks' gestation supported by Seattle-PAP will have lower rates of continuous positive airway pressure (CPAP) failure than infants supported with conventional, Fisher&Paykel-CPAP (FP-CPAP). STUDY

DESIGN:

Randomized trial (3/2017-01/2019) at 5 NICUs. The primary outcome was CPAP failure; subgroup analyses (gestational age, receipt antenatal corticosteroids) were performed.

RESULTS:

A total of 232 infants were randomized. Infants in the Seattle-PAP and FP-CPAP groups had mean gestational ages of 27.0 and 27.2 weeks, respectively. We observed no differences in rates of treatment failure between Seattle-PAP (40/112, 35.7%) and FP-CPAP (38/120, 31.7%; risk difference, 4.1%; 95% CI, -8.1-16.2; P = 0.51). Subgroup analysis indicated no differences in rates of CPAP failure. We observed no differences between the two groups in frequencies of adverse events or duration of respiratory support.

CONCLUSIONS:

Among infants born <30 weeks' gestation, rates of CPAP failure did not differ between Seattle-PAP and FP-CPAP.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Distress Syndrome, Newborn / Continuous Positive Airway Pressure Limits: Female / Humans / Infant / Newborn / Pregnancy Language: En Journal: J Perinatol Journal subject: PERINATOLOGIA Year: 2020 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Distress Syndrome, Newborn / Continuous Positive Airway Pressure Limits: Female / Humans / Infant / Newborn / Pregnancy Language: En Journal: J Perinatol Journal subject: PERINATOLOGIA Year: 2020 Document type: Article Affiliation country: United States