Comparison of acute treatment with delayed-onset versus rapid-acting antidepressants on effort-related choice behaviour.
Psychopharmacology (Berl)
; 237(8): 2381-2394, 2020 Aug.
Article
in En
| MEDLINE
| ID: mdl-32435818
ABSTRACT
RATIONALE Reward-related impairments are common in major depressive disorder (MDD) and may contribute to the loss of interest in pleasurable activities. A novel approach to studying reward-related decision-making are effort-based tasks; however, direct comparisons between delayed-onset and rapid-acting antidepressants (ADs) have not yet been carried out. OBJECTIVES:
To investigate the effects of conventional delayed-onset ADs versus rapid-acting ADs, ketamine and scopolamine, on effort-related choice behaviour.METHODS:
Female Lister hooded rats were trained in an operant effort for reward task (EfRT) where animals choose between working for a high value-high effort reward and consuming low value-low effort chow. Using a within-subject study design, animals were then tested following acute treatment with different monoaminergic ADs, and the rapid-acting ADs ketamine or scopolamine.RESULTS:
Consistent with previous findings, we found choice behaviour was sensitive to dopaminergic manipulations. We observed that pre-feeding altered choice behaviour and that the use of high or low value reward differentially affected behaviour. Monoamine re-uptake inhibitors and rapid-acting ADs resulted in similar, general patterns of reduced motivation without any evidence for specific effects, and we did not observe any clear differences between these classes of antidepressant.CONCLUSIONS:
Motivational changes induced by dopaminergic manipulations and pre-feeding differentially affect effort choice behaviour. However, both conventional delayed-onset ADs and ketamine and scopolamine appear to have detrimental effects on motivation in this task at the higher doses tested without any evidence of specificity for effort-related choice behaviour, in contrast to their specificity in tasks which look at more cognitive aspects of reward processing.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reward
/
Choice Behavior
/
Motivation
/
Antidepressive Agents
Limits:
Animals
Language:
En
Journal:
Psychopharmacology (Berl)
Year:
2020
Document type:
Article
Affiliation country:
United kingdom