Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network.

Brandt, Zachary J; Echert, Ashley E; Bostrom, Jonathan R; North, Paula N; Link, Brian A

Brandt, Zachary J; Echert, Ashley E; Bostrom, Jonathan R; North, Paula N; Link, Brian A.

Affiliation

Brandt ZJ; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Wauwatosa, WI 53226, USA.
Echert AE; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Wauwatosa, WI 53226, USA.
Bostrom JR; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Wauwatosa, WI 53226, USA.
North PN; Department of Pediatric Pathology, Medical College of Wisconsin, Wauwatosa, WI 53226, USA.
Link BA; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Wauwatosa, WI 53226, USA blink@mcw.edu.

Development ; 147(12)2020 06 22.

Article in En | MEDLINE | ID: mdl-32439761

Subject(s)

Biliary Tract/metabolism; Protein Serine-Threonine Kinases/metabolism; Trans-Activators/metabolism; Transcription Factors/metabolism; Zebrafish Proteins/metabolism; Acyltransferases; Animals; Animals, Genetically Modified/growth & development; Animals, Genetically Modified/metabolism; Biliary Tract/anatomy & histology; Biliary Tract/growth & development; CRISPR-Cas Systems/genetics; Carboxylic Ester Hydrolases/metabolism; Gallbladder/anatomy & histology; Gallbladder/growth & development; Gallbladder/metabolism; Larva/growth & development; Larva/metabolism; Liver/anatomy & histology; Liver/metabolism; Phenotype; Protein Serine-Threonine Kinases/deficiency; Protein Serine-Threonine Kinases/genetics; Serine-Threonine Kinase 3; Signal Transduction; Trans-Activators/genetics; Transcription Factors/genetics; YAP-Signaling Proteins; Zebrafish/growth & development; Zebrafish/metabolism; Zebrafish Proteins/deficiency; Zebrafish Proteins/genetics

Key words

Cholangiocarcinoma; Gallbladder; Hepatopancreatic ductal system; Hippo pathway; Sav1; Stk3

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Biliary Tract / Trans-Activators / Protein Serine-Threonine Kinases / Zebrafish Proteins Limits: Animals Language: En Journal: Development Journal subject: BIOLOGIA / EMBRIOLOGIA Year: 2020 Document type: Article Affiliation country: United States

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