Considering discrepancy when calibrating a mechanistic electrophysiology model.
Philos Trans A Math Phys Eng Sci
; 378(2173): 20190349, 2020 Jun 12.
Article
in En
| MEDLINE
| ID: mdl-32448065
ABSTRACT
Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations to take decisions. The field of cardiac simulation has begun to explore and adopt UQ methods to characterize uncertainty in model inputs and how that propagates through to outputs or predictions; examples of this can be seen in the papers of this issue. In this review and perspective piece, we draw attention to an important and under-addressed source of uncertainty in our predictions-that of uncertainty in the model structure or the equations themselves. The difference between imperfect models and reality is termed model discrepancy, and we are often uncertain as to the size and consequences of this discrepancy. Here, we provide two examples of the consequences of discrepancy when calibrating models at the ion channel and action potential scales. Furthermore, we attempt to account for this discrepancy when calibrating and validating an ion channel model using different methods, based on modelling the discrepancy using Gaussian processes and autoregressive-moving-average models, then highlight the advantages and shortcomings of each approach. Finally, suggestions and lines of enquiry for future work are provided. This article is part of the theme issue 'Uncertainty quantification in cardiac and cardiovascular modelling and simulation'.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Electrophysiological Phenomena
/
Models, Cardiovascular
Type of study:
Prognostic_studies
Language:
En
Journal:
Philos Trans A Math Phys Eng Sci
Journal subject:
BIOFISICA
/
ENGENHARIA BIOMEDICA
Year:
2020
Document type:
Article
Affiliation country:
United kingdom
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM