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Response surface optimization of phenolic compounds from jabuticaba (Myrciaria cauliflora [Mart.] O.Berg) seeds: Antioxidant, antimicrobial, antihyperglycemic, antihypertensive and cytotoxic assessments.
Fidelis, Marina; Vieira do Carmo, Mariana Araújo; Azevedo, Luciana; Cruz, Thiago Mendanha; Marques, Mariza Boscacci; Myoda, Takao; Sant'Ana, Anderson S; Furtado, Marianna Miranda; Wen, Mingchun; Zhang, Liang; Rosso, Neiva Deliberali; Genovese, Maria Inês; Oh, Won Young; Shahidi, Fereidoon; Pap, Nora; Granato, Daniel.
Affiliation
  • Fidelis M; Graduate Program in Food Science and Technology, State University of Ponta Grossa. Avenida Carlos Cavalcanti, 4748, 84030-900, Ponta Grossa, Brazil.
  • Vieira do Carmo MA; Faculty of Nutrition, Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 714, 37130-000, Alfenas, MG, Brazil.
  • Azevedo L; Faculty of Nutrition, Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 714, 37130-000, Alfenas, MG, Brazil.
  • Cruz TM; Department of Chemistry, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, 84030-900, Ponta Grossa, PR, Brazil.
  • Marques MB; Department of Chemistry, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, 84030-900, Ponta Grossa, PR, Brazil.
  • Myoda T; Department of Food Sciences and Technology, Tokyo University of Agriculture, Abashiri, 099-2493, Japan.
  • Sant'Ana AS; Department of Food Science, Faculty of Food Engineering, University of Campinas, Campinas, SP, Brazil.
  • Furtado MM; Department of Food Science, Faculty of Food Engineering, University of Campinas, Campinas, SP, Brazil.
  • Wen M; State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, 230036, China.
  • Zhang L; State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, 230036, China.
  • Rosso ND; Graduate Program in Food Science and Technology, State University of Ponta Grossa. Avenida Carlos Cavalcanti, 4748, 84030-900, Ponta Grossa, Brazil.
  • Genovese MI; Laboratory of Bioactive Compounds, Food and Experimental Nutrition Department, University of São Paulo, 05508-900, São Paulo, SP, Brazil.
  • Oh WY; Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL, A1B 3X9, Canada.
  • Shahidi F; Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL, A1B 3X9, Canada.
  • Pap N; Biorefinery and Bioproducts, Natural Resources Institute Finland (Luke), FI-31600, Jokioinen, Finland.
  • Granato D; Graduate Program in Food Science and Technology, State University of Ponta Grossa. Avenida Carlos Cavalcanti, 4748, 84030-900, Ponta Grossa, Brazil; Food Processing and Quality, Natural Resources Institute Finland (Luke), FI-02150, Espoo, Finland. Electronic address: Daniel.granato@luke.fi.
Food Chem Toxicol ; 142: 111439, 2020 Aug.
Article in En | MEDLINE | ID: mdl-32450285
ABSTRACT
The aim of this study was to evaluate the effects of different solvents and maximize the extraction of bioactive compounds from jabuticaba (Myrciaria cauliflora) seeds. In general, the solvent system composed of water and propanone (5248 v/v) modified the extract polarity and increased extraction yield of bioactive compounds. The optimized extract presented antioxidant capacity measured by different chemical and biological assays. The optimized extract exerted antiproliferative and cytotoxic effects against A549 and HCT8 cells, antimicrobial and antihemolytic effects, inhibited α-amylase/α-glucosidase activities and presented in vitro antihypertensive effect. Nonetheless, the optimized extract showed no cytotoxicity in a human cell model (IMR90). Vescalagin, castalagin and ellagic acid were the major phenolic compounds in the optimized extract. Our results show that jabuticaba seed may be a potential ingredient for the development of potentially functional foods.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Seeds / Plant Extracts / Myrtaceae Limits: Humans Language: En Journal: Food Chem Toxicol Year: 2020 Document type: Article Affiliation country: Brazil
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Seeds / Plant Extracts / Myrtaceae Limits: Humans Language: En Journal: Food Chem Toxicol Year: 2020 Document type: Article Affiliation country: Brazil