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Photothermal modulation of human stem cells using light-responsive 2D nanomaterials.
Carrow, James K; Singh, Kanwar Abhay; Jaiswal, Manish K; Ramirez, Adelina; Lokhande, Giriraj; Yeh, Alvin T; Sarkar, Tapasree Roy; Singh, Irtisha; Gaharwar, Akhilesh K.
Affiliation
  • Carrow JK; Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843.
  • Singh KA; Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843.
  • Jaiswal MK; Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843.
  • Ramirez A; Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843.
  • Lokhande G; Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843.
  • Yeh AT; Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843.
  • Sarkar TR; Department of Biology, Texas A&M University, College Station, TX 77843.
  • Singh I; Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843; gaharwar@tamu.edu isingh@tamu.edu.
  • Gaharwar AK; Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, Texas A&M University, Bryan, TX 77807.
Proc Natl Acad Sci U S A ; 117(24): 13329-13338, 2020 06 16.
Article in En | MEDLINE | ID: mdl-32461372
ABSTRACT
Two-dimensional (2D) molybdenum disulfide (MoS2) nanomaterials are an emerging class of biomaterials that are photoresponsive at near-infrared wavelengths (NIR). Here, we demonstrate the ability of 2D MoS2 to modulate cellular functions of human stem cells through photothermal mechanisms. The interaction of MoS2 and NIR stimulation of MoS2 with human stem cells is investigated using whole-transcriptome sequencing (RNA-seq). Global gene expression profile of stem cells reveals significant influence of MoS2 and NIR stimulation of MoS2 on integrins, cellular migration, and wound healing. The combination of MoS2 and NIR light may provide new approaches to regulate and direct these cellular functions for the purposes of regenerative medicine as well as cancer therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nanostructures / Disulfides / Mesenchymal Stem Cells / Molybdenum Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nanostructures / Disulfides / Mesenchymal Stem Cells / Molybdenum Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA