Convergent Total Synthesis of Lamellarins and Their Congeners.
J Org Chem
; 85(13): 8603-8617, 2020 07 02.
Article
in En
| MEDLINE
| ID: mdl-32462869
ABSTRACT
A convergent total synthesis of lamellarins S and Z is described. The synthesis features a halogen dance of an easily accessible α,ß-dibromopyrrole promoted by an ester moiety. The resultant ß,ß'-dibromopyrrole undergoes a ligand-controlled Suzuki-Miyaura coupling to provide a range of diarylated pyrrole derivatives. The established synthetic method was also applicable to the synthesis of ningalin B and lukianols A and B.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2020
Document type:
Article
Affiliation country:
Japan