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Fluorogenic iminosydnones: bioorthogonal tools for double turn-on click-and-release reactions.
Riomet, Margaux; Porte, Karine; Wijkhuisen, Anne; Audisio, Davide; Taran, Frédéric.
Affiliation
  • Riomet M; Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France. frederic.taran@cea.fr.
Chem Commun (Camb) ; 56(52): 7183-7186, 2020 Jul 04.
Article in En | MEDLINE | ID: mdl-32463407
ABSTRACT
In this article, we report the synthesis and use of iminosydnone-based profluorophores as bioorthogonal cleavable linkers for imaging applications. These linkers react with cycloalkynes via subsequent [3+2] cycloaddition and retro Diels-Alder reactions, allowing simultaneous release of two dyes in biological media.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sydnones / Fluorescent Dyes Limits: Animals Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sydnones / Fluorescent Dyes Limits: Animals Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: France