Landmark clinical observations and immunopathogenesis pathways linked to HIV and Cryptococcus fatal central nervous system co-infection.

Okurut, Samuel; Boulware, David R; Olobo, Joseph; Meya, David B

Okurut, Samuel; Boulware, David R; Olobo, Joseph; Meya, David B.

Affiliation

Okurut S; Research Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Boulware DR; Department of Microbiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
Olobo J; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
Meya DB; Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.

Mycoses ; 63(8): 840-853, 2020 Aug.

Article in En | MEDLINE | ID: mdl-32472727

Subject(s)

HIV Infections/complications; Meningitis, Cryptococcal; AIDS-Related Opportunistic Infections/epidemiology; AIDS-Related Opportunistic Infections/immunology; AIDS-Related Opportunistic Infections/pathology; AIDS-Related Opportunistic Infections/therapy; B-Lymphocytes/immunology; B-Lymphocytes/metabolism; B7-H1 Antigen/blood; B7-H1 Antigen/isolation & purification; Brain/immunology; Brain/parasitology; Cerebrospinal Fluid/immunology; Coinfection; Cryptococcosis/etiology; Cryptococcus/isolation & purification; Cryptococcus/pathogenicity; Cryptococcus gattii/isolation & purification; Cryptococcus gattii/pathogenicity; Cryptococcus neoformans/isolation & purification; Cryptococcus neoformans/pathogenicity; Humans; Immunity; Incidence; Inflammation; Meningitis, Cryptococcal/epidemiology; Meningitis, Cryptococcal/immunology; Meningitis, Cryptococcal/pathology; Meningitis, Cryptococcal/therapy; Mortality; Prevalence; Programmed Cell Death 1 Receptor/blood; Programmed Cell Death 1 Receptor/isolation & purification; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; Treatment Outcome

Key words

B-cell immune regulation; HIV-associated cryptococcal meningitis co-infection; Human Cryptococcus infection; PD-1/PD-L1 immune regulation; brain fibrosis; central nervous system evasion; immune activation; pathogenesis; treatment outcome

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Meningitis, Cryptococcal Type of study: Etiology_studies / Incidence_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Mycoses Journal subject: MICROBIOLOGIA Year: 2020 Document type: Article Affiliation country: Uganda

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google