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Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agents overlooked by tissue RNA-seq.
Takashima, Tsuyoshi; Sakamoto, Naoya; Murai, Junko; Taniyama, Daiki; Honma, Ririno; Ukai, Shoichi; Maruyama, Ryota; Kuraoka, Kazuya; Rajapakse, Vinodh N; Pommier, Yves; Yasui, Wataru.
Affiliation
  • Takashima T; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
  • Sakamoto N; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
  • Murai J; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, 997-0052, Japan.
  • Taniyama D; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
  • Honma R; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
  • Ukai S; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
  • Maruyama R; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan.
  • Kuraoka K; Department of Diagnostic Pathology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure city, Hiroshima, 737-0023, Japan.
  • Rajapakse VN; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
  • Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
  • Yasui W; Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8551, Japan. wyasui@hiroshima-u.ac.jp.
Virchows Arch ; 478(3): 569-579, 2021 Mar.
Article in En | MEDLINE | ID: mdl-32474729
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Immunohistochemistry / Nuclear Proteins / Biomarkers, Tumor / Drug Resistance, Neoplasm / RNA-Seq / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: Virchows Arch Journal subject: BIOLOGIA MOLECULAR / PATOLOGIA Year: 2021 Document type: Article Affiliation country: Japan Country of publication: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Immunohistochemistry / Nuclear Proteins / Biomarkers, Tumor / Drug Resistance, Neoplasm / RNA-Seq / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: Virchows Arch Journal subject: BIOLOGIA MOLECULAR / PATOLOGIA Year: 2021 Document type: Article Affiliation country: Japan Country of publication: Germany