Transformation of Grade I Follicular Lymphoma to Anaplastic Large Cell Lymphoma CD30+ ALK1- with Complete Response to Brentuximab Vedotin and High-Dose Methotrexate.
Gulf J Oncolog
; 1(33): 87-90, 2020 May.
Article
in En
| MEDLINE
| ID: mdl-32476657
ABSTRACT
Lymphomas are a heterogeneous group of diseases that encompass malignant disorders of B-cells, T-cells, or natural killer cells. B-cell lymphomas represent approximately 80-85% of cases. Transformation of B-cell lymphomas from a low grade to a higher grade within the same lineage is a well-described phenomenon. The most common and well-known transformation is from follicular lymphoma to diffuse large B-cell lymphoma. However, the transformation of B-cell lymphomas to T-cell lymphomas is extremely rare. In this article, we report a case of grade I follicular lymphoma (B-cell lymphoma) that transformed into anaplastic large cell lymphoma CD30+ ALK1- (T-cell lymphoma). This article reported a case with a unique particular combination of morphology and immunophenotype in the same patient. In addition, we report a remarkable response with complete remission following treatment with Brentuximab vedotin (anti-CD30 antibody-drug conjugate) and high-dose methotrexate. The patient achieved this durable response despite the aggressive presentation.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Methotrexate
/
Lymphoma, Follicular
/
Lymphoma, Large-Cell, Anaplastic
/
Antineoplastic Agents, Immunological
/
Brentuximab Vedotin
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Gulf J Oncolog
Journal subject:
NEOPLASIAS
Year:
2020
Document type:
Article
Affiliation country:
Saudi Arabia