Absence of Nocturnal Fall in Blood Pressure Detected by Ambulatory Blood Pressure Monitoring in Acute Chagas Disease Patients with Oral Infection. / Ausência de Descenso da Pressão Arterial Detectada pela Monitorização Ambulatorial da Pressão Arterial em Pacientes com Doença de Chagas Aguda Transmitida por Via Oral.
Arq Bras Cardiol
; 114(4): 711-715, 2020 04.
Article
in En, Pt
| MEDLINE
| ID: mdl-32491012
ABSTRACT
Background The involvement of the autonomic nervous system is one of the mechanisms proposed to explain the progression of myocardial lesion in Chagas disease. Evidences have shown changes in sympathetic and parasympathetic nervous system since the acute phase of the disease, and studies to clarify the pathophysiological and prognostic value of these changes are needed. Objetives To assess blood pressure profile by ambulatory blood pressure monitoring (ABPM) in normotensive patients with acute Chagas disease (ACD) without apparent cardiac damage, and the influence of the infection on nocturnal blood pressure fall. Methods ABPM was performed with 54 patients with ACD and a control group composed of 54 age- and sex-matched normotensive individuals. The alpha level of significance (type I error rate) was set at 5%. Results In the total of 54 patients, 74.0% did not show nocturnal fall in systolic blood pressure, 53.7% did not show nocturnal fall in diastolic blood pressure, and lack of both nocturnal fall in SBP and DBP was observed in 51.8% (*p<0.05). In 12.9% of patients, there was an increase in SBP and in 18.5% increase in DBP (p<0.05). Conclusions In patients with acute Chagas disease, a significant absence of the physiological fall in both systolic and diastolic blood pressure was observed during sleep, and some of the patients showed nocturnal increase in these parameters. These findings suggest autonomic changes in the acute phase of Chagas disease. (Arq Bras Cardiol. 2020; 114(4)711-715).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chagas Disease
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
/
Pt
Journal:
Arq Bras Cardiol
Year:
2020
Document type:
Article
Affiliation country:
Brazil
Publication country:
BR
/
BRASIL
/
BRASILE
/
BRAZIL
/
BRESIL