Binding Site Interactions of Modulators of Breast Cancer Resistance Protein, Multidrug Resistance-Associated Protein 2, and P-Glycoprotein Activity.

Deng, Feng; Ghemtio, Leo; Grazhdankin, Evgeni; Wipf, Peter; Xhaard, Henri; Kidron, Heidi

Deng, Feng; Ghemtio, Leo; Grazhdankin, Evgeni; Wipf, Peter; Xhaard, Henri; Kidron, Heidi.

Affiliation

Deng F; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki 00014, Finland.
Ghemtio L; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki 00014, Finland.
Grazhdankin E; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki 00014, Finland.
Wipf P; Department of Chemistry, The Center for Chemical Methodologies and Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.
Xhaard H; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki 00014, Finland.
Kidron H; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki 00014, Finland.

Mol Pharm ; 17(7): 2398-2410, 2020 07 06.

Article in En | MEDLINE | ID: mdl-32496785

Subject(s)

ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism; Antineoplastic Agents/metabolism; Catalytic Domain; Multidrug Resistance-Associated Proteins/metabolism; Neoplasm Proteins/metabolism; ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily B/chemistry; ATP Binding Cassette Transporter, Subfamily B/metabolism; ATP Binding Cassette Transporter, Subfamily G, Member 2/antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily G, Member 2/chemistry; Antineoplastic Agents/pharmacology; Biological Transport, Active/drug effects; Humans; Ligands; Molecular Docking Simulation; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins/antagonists & inhibitors; Multidrug Resistance-Associated Proteins/chemistry; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/chemistry

Key words

drug transporter; efflux; inhibitor; modulator; stimulator

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Catalytic Domain / Multidrug Resistance-Associated Proteins / ATP Binding Cassette Transporter, Subfamily G, Member 2 / Neoplasm Proteins / Antineoplastic Agents Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2020 Document type: Article Affiliation country: Finland

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google