The structure of human CST reveals a decameric assembly bound to telomeric DNA.

Lim, Ci Ji; Barbour, Alexandra T; Zaug, Arthur J; Goodrich, Karen J; McKay, Allison E; Wuttke, Deborah S; Cech, Thomas R

Lim, Ci Ji; Barbour, Alexandra T; Zaug, Arthur J; Goodrich, Karen J; McKay, Allison E; Wuttke, Deborah S; Cech, Thomas R.

Affiliation

Lim CJ; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.
Barbour AT; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
Zaug AJ; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.
Goodrich KJ; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.
McKay AE; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
Wuttke DS; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
Cech TR; Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA.

Science ; 368(6495): 1081-1085, 2020 06 05.

Article in En | MEDLINE | ID: mdl-32499435

Subject(s)

Multiprotein Complexes/chemistry; Telomere Homeostasis; Telomere-Binding Proteins/chemistry; Telomere/chemistry; Cryoelectron Microscopy; DNA, Single-Stranded/chemistry; HEK293 Cells; Humans; Protein Binding; Protein Domains; Protein Multimerization; Replication Protein A/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telomere / Telomere-Binding Proteins / Multiprotein Complexes / Telomere Homeostasis Type of study: Prognostic_studies Limits: Humans Language: En Journal: Science Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States

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