Enhanced tendon restoration effects of anti-inflammatory, lactoferrin-immobilized, heparin-polymeric nanoparticles in an Achilles tendinitis rat model.

Choi, Hong Joon; Choi, Somang; Kim, Jae Gyoon; Song, Mi Hyun; Shim, Kyu-Sik; Lim, Youn-Mook; Kim, Hak-Jun; Park, Kyeongsoon; Kim, Sung Eun

Choi, Hong Joon; Choi, Somang; Kim, Jae Gyoon; Song, Mi Hyun; Shim, Kyu-Sik; Lim, Youn-Mook; Kim, Hak-Jun; Park, Kyeongsoon; Kim, Sung Eun.

Affiliation

Choi HJ; Department of Orthopedic Surgery, College of Medicine Korea University, Anam-dong, Seongbuk-gu, Seoul, 02841, Republic of Korea; Yonsei gunwoo Hospital, #1814, Nambusunhwan-ro, Gwanak-gu, Seoul, 08787, Republic of Korea.
Choi S; Department of Biomedical Science, College of Medicine Korea University, Anam-dong, Seongbuk-gu, Seoul, 02841, Republic of Korea.
Kim JG; Department of Orthopedic Surgery, Korea University, College of Medicine, Korea University Ansan Hospital 123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, 15355, Republic of Korea.
Song MH; Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Guro Hospital, #80, Guro-dong, Guro-gu, Seoul, 08308, Republic of Korea.
Shim KS; Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Guro Hospital, #80, Guro-dong, Guro-gu, Seoul, 08308, Republic of Korea.
Lim YM; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeollabuk-do, 56212, Republic of Korea.
Kim HJ; Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Guro Hospital, #80, Guro-dong, Guro-gu, Seoul, 08308, Republic of Korea. Electronic address: dakjul@korea.ac.kr.
Park K; Department of Systems Biotechnology, Chung-Ang University, Anseong, Gyeonggi, 17546, Republic of Korea. Electronic address: kspark1223@cau.ac.kr.
Kim SE; Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Guro Hospital, #80, Guro-dong, Guro-gu, Seoul, 08308, Republic of Korea. Electronic address: sekim10@korea.ac.kr.

Carbohydr Polym ; 241: 116284, 2020 Aug 01.

Article in En | MEDLINE | ID: mdl-32507170

Subject(s)

Achilles Tendon/drug effects; Anti-Inflammatory Agents/administration & dosage; Heparin/administration & dosage; Lactoferrin/administration & dosage; Nanoparticles/administration & dosage; Polylactic Acid-Polyglycolic Acid Copolymer/administration & dosage; Tendinopathy/drug therapy; Achilles Tendon/metabolism; Achilles Tendon/pathology; Achilles Tendon/physiology; Animals; Anti-Inflammatory Agents/chemistry; Collagen/metabolism; Cytokines/genetics; Disease Models, Animal; Heparin/chemistry; Lactoferrin/chemistry; Male; Nanoparticles/chemistry; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry; Rats, Sprague-Dawley; Tendinopathy/genetics; Tendinopathy/metabolism; Tendinopathy/pathology; Tenocytes/drug effects; Tensile Strength

Key words

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) (PubChem CID: 2723939); 2-(N-morpholino)-ethanesulfonic acid (PubChem CID:4478249); Dichloromethane (DCM) (PubChem CID: 6344); Dopamine hydrochloride (PubChem CID:65340); Heparin sodium (PubChem CID: 22833565); Lactoferrin (PubChem CID: 126456119, Mw: 3128.8â¯g/mol); N-hydroxysuccinimide (NHS) (PubChem CID: 80170); Poly (lactic-co-glycolic acid) (PLGA) (PubChem CID: 23111554); Polyvinyl Alcohol (PVA) (PubChem CID: 11199); Sodium Chloride (PubChem CID:5234); inflammatory factors; nanoparticles; sustained lactoferrin delivery; tendon healing; tenocytes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Achilles Tendon / Heparin / Tendinopathy / Nanoparticles / Polylactic Acid-Polyglycolic Acid Copolymer / Lactoferrin / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Carbohydr Polym Year: 2020 Document type: Article Country of publication: United kingdom

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