Drug dosing in the critically ill obese patient-a focus on sedation, analgesia, and delirium.
Crit Care
; 24(1): 315, 2020 06 08.
Article
in En
| MEDLINE
| ID: mdl-32513237
ABSTRACT
Practice guidelines provide clear evidence-based recommendations for the use of drug therapy to manage pain, agitation, and delirium associated with critical illness. Dosing recommendations however are often based on strategies used in patients with normal body habitus. Recommendations specific to critically ill patients with extreme obesity are lacking. Nonetheless, clinicians must craft dosing regimens for this population. This paper is intended to help clinicians design initial dosing regimens for medications commonly used in the management of pain, agitation, and delirium in critically ill patients with extreme obesity. A detailed literature search was conducted with an emphasis on obesity, pharmacokinetics, and dosing. Relevant manuscripts were reviewed and strategies for dosing are provided.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Delirium
/
Dose-Response Relationship, Drug
/
Deep Sedation
/
Analgesia
/
Obesity
Type of study:
Guideline
Limits:
Humans
Language:
En
Journal:
Crit Care
Year:
2020
Document type:
Article
Affiliation country:
United States