The MNK1/2-eIF4E Axis as a Potential Therapeutic Target in Melanoma.

Prabhu, Sathyen A; Moussa, Omar; Miller, Wilson H; Del Rincón, Sonia V

Prabhu, Sathyen A; Moussa, Omar; Miller, Wilson H; Del Rincón, Sonia V.

Affiliation

Prabhu SA; Division of Experimental Medicine, McGill University, 1001 Decarie Boulevard, Montreal, QC H4A 3J1, Canada.
Moussa O; Lady Davis Institute, Jewish General Hospital, McGill University, 3755 Côte Ste-Catherine Road, Montreal, QC H3T 1E2, Canada.
Miller WH; Division of Experimental Medicine, McGill University, 1001 Decarie Boulevard, Montreal, QC H4A 3J1, Canada.
Del Rincón SV; Lady Davis Institute, Jewish General Hospital, McGill University, 3755 Côte Ste-Catherine Road, Montreal, QC H3T 1E2, Canada.

Int J Mol Sci ; 21(11)2020 Jun 05.

Article in En | MEDLINE | ID: mdl-32517051

Subject(s)

Eukaryotic Initiation Factor-4E/metabolism; Intracellular Signaling Peptides and Proteins/metabolism; Melanoma/etiology; Melanoma/metabolism; Protein Serine-Threonine Kinases/metabolism; Signal Transduction; Animals; Biomarkers, Tumor; Combined Modality Therapy; Disease Management; Disease Susceptibility; Humans; Immunotherapy; Melanoma/drug therapy; Melanoma/pathology; Molecular Diagnostic Techniques; Molecular Targeted Therapy; Signal Transduction/drug effects; Translational Research, Biomedical; Treatment Outcome

Key words

MNK1; eIF4E; immunotherapy; melanoma; translation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Protein Serine-Threonine Kinases / Eukaryotic Initiation Factor-4E / Intracellular Signaling Peptides and Proteins / Melanoma Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2020 Document type: Article Affiliation country: Canada Country of publication: Switzerland

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