The Hepatotoxicity of Alantolactone and Germacrone: Their Influence on Cholesterol and Lipid Metabolism in Differentiated HepaRG Cells.

Zárybnický, Tomás; Matousková, Petra; Skálová, Lenka; Bousová, Iva

Zárybnický, Tomás; Matousková, Petra; Skálová, Lenka; Bousová, Iva.

Affiliation

Zárybnický T; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University, 500 05 Hradec Králové, Czech Republic.
Matousková P; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University, 500 05 Hradec Králové, Czech Republic.
Skálová L; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University, 500 05 Hradec Králové, Czech Republic.
Bousová I; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University, 500 05 Hradec Králové, Czech Republic.

Nutrients ; 12(6)2020 Jun 08.

Article in En | MEDLINE | ID: mdl-32521813

Subject(s)

Antineoplastic Agents, Phytogenic/toxicity; Cell Survival/drug effects; Cholesterol/metabolism; Lactones/toxicity; Lipid Metabolism/drug effects; Liver/metabolism; Sesquiterpenes, Eudesmane/toxicity; Sesquiterpenes, Germacrane/toxicity; Gene Expression/drug effects; Hep G2 Cells; Humans; Hydroxymethylglutaryl CoA Reductases/genetics; Hydroxymethylglutaryl CoA Reductases/metabolism; Intercellular Adhesion Molecule-1/metabolism; NF-kappa B/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reactive Oxygen Species/metabolism; STAT3 Transcription Factor/metabolism; Sterol Regulatory Element Binding Protein 2/genetics; Sterol Regulatory Element Binding Protein 2/metabolism

Key words

HepaRG cells; alantolactone; germacrone; liver toxicity; metabolic dysregulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Survival / Cholesterol / Sesquiterpenes, Eudesmane / Sesquiterpenes, Germacrane / Lipid Metabolism / Lactones / Liver / Antineoplastic Agents, Phytogenic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nutrients Year: 2020 Document type: Article Affiliation country: Czech Republic

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