Palladium-Catalyzed Carbonylative Annulation of 1-Hydroxy-o-Carborane and Internal Alkynes via Regioselective B-H Activation.
Chem Asian J
; 15(14): 2170-2173, 2020 Jul 16.
Article
in En
| MEDLINE
| ID: mdl-32533620
ABSTRACT
A Pd-catalyzed three-component carbonylative-annulation of 1-hydroxy-o-carborane, internal alkyne and carbon monoxide has been achieved via direct and regioselective cage B-H activation. A class of C,B-substituted carborano-coumarin derivatives with potential applications in pharmaceuticals were facilely prepared in moderate to high yields with excellent chemoselectivity and regioselectivity. A plausible reaction mechanism including CO insertion, electrophilic B-H metalation, alkyne insertion and reductive elimination was proposed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Asian J
Year:
2020
Document type:
Article
Affiliation country:
China