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A novel diclofenac-hydrogel conjugate system for intraarticular sustained release: Development of 2-pyridylamino-substituted 1-phenylethanol (PAPE) and its derivatives as tunable traceless linkers.
Kawanami, Toshio; LaBonte, Laura R; Amin, Jakal; Thibodeaux, Stefan J; Lee, Cameron C; Argintaru, O Andreea; Adams, Christopher M.
Affiliation
  • Kawanami T; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, United States. Electronic address: toshio.kawanami@novartis.com.
  • LaBonte LR; Pharmacokinetic Sciences, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
  • Amin J; Analytical Sciences and Imaging, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
  • Thibodeaux SJ; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, United States.
  • Lee CC; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, United States.
  • Argintaru OA; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, United States.
  • Adams CM; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, United States.
Int J Pharm ; 585: 119519, 2020 Jul 30.
Article in En | MEDLINE | ID: mdl-32535069
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzyl Alcohols / Anti-Inflammatory Agents, Non-Steroidal / Diclofenac / Drug Delivery Systems / Hydrogels Limits: Animals / Humans Language: En Journal: Int J Pharm Year: 2020 Document type: Article Country of publication: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzyl Alcohols / Anti-Inflammatory Agents, Non-Steroidal / Diclofenac / Drug Delivery Systems / Hydrogels Limits: Animals / Humans Language: En Journal: Int J Pharm Year: 2020 Document type: Article Country of publication: Netherlands