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Association between Fetal MTHFR A1298C (rs1801131) Polymorphism and Neural Tube Defects Risk: A Systematic Review and Meta-Analysis.
Soleimani-Jadidi, Sara; Meibodi, Bahare; Javaheri, Atiyeh; Tabatabaei, Razieh Sadat; Hadadan, Amaneh; Zanbagh, Leila; Abbasi, Hajar; Bahrami, Reza; Mirjalili, Seyed Reza; Karimi-Zarchi, Mojgan; Neamatzadeh, Hossein.
Affiliation
  • Soleimani-Jadidi S; Department of Obstetrics and Gynecology, Lorestan University of Medical Sciences, Lorestan, Iran.
  • Meibodi B; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Javaheri A; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Tabatabaei RS; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Hadadan A; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Zanbagh L; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Abbasi H; Department of Obstetrics and Gynecology, Yazd Branch, Islamic Azad University, Yazd, Iran.
  • Bahrami R; Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mirjalili SR; Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Karimi-Zarchi M; Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Neamatzadeh H; Mother and Newborn Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fetal Pediatr Pathol ; 41(1): 116-133, 2022 Feb.
Article in En | MEDLINE | ID: mdl-32536231
ABSTRACT

BACKGROUND:

The association of the fetal MTHFR A1298C (rs1801131) polymorphism and neural tube defects (NTDs) susceptibility has been widely demonstrated, but the results remain inconclusive. Thus, we performed a meta-analysis to investigate the association between fetal MTHFR A1298C polymorphism and NTDs risk.

METHODS:

An electronic search of PubMed, web of science, SciELO, CNKI database for studies on the fetal MTHFR A1298C polymorphism and NTDs risk was performed up to March 30, 2020.

RESULTS:

A total of 22 case-control studies with 3,224 fetuses with NTDs and 3,295 controls were selected. Overall, pooled data showed that the fetal MTHFR A1298C polymorphism was not significantly associated with risk an increased risk of NTDs in the global population. When stratified analysis by ethnicity, country of origin and NTDs type, still no statistically significant association was found.

CONCLUSIONS:

Our pooled data emerged no evidence for significant association between fetal MTHFR A1298C polymorphism and NTDs risk.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Methylenetetrahydrofolate Reductase (NADPH2) / Neural Tube Defects Type of study: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limits: Female / Humans / Pregnancy Language: En Journal: Fetal Pediatr Pathol Journal subject: PATOLOGIA / PEDIATRIA Year: 2022 Document type: Article Affiliation country: Iran
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Methylenetetrahydrofolate Reductase (NADPH2) / Neural Tube Defects Type of study: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limits: Female / Humans / Pregnancy Language: En Journal: Fetal Pediatr Pathol Journal subject: PATOLOGIA / PEDIATRIA Year: 2022 Document type: Article Affiliation country: Iran