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Ursolic acid potentiated oxaliplatin to induce apoptosis in colorectal cancer RKO cells.
Zheng, Jia -Lu; Wang, Shuang-Shuang; Shen, Ke-Ping; Huang, Xiao-Wei; Li, Miao; Chen, Lei; Peng, Xiao; An, Hong-Mei; Hu, Bing.
Affiliation
  • Zheng J-; Institute of Traditional Chinese Medicine in Oncology, Shanghai, P. R. China; Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
  • Wang SS; Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
  • Shen KP; Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
  • Huang XW; Institute of Traditional Chinese Medicine in Oncology, Shanghai, P. R. China; Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
  • Li M; Institute of Traditional Chinese Medicine in Oncology, Shanghai, P. R. China; Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
  • Chen L; Institute of Traditional Chinese Medicine in Oncology, Shanghai, P. R. China; Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
  • Peng X; Institute of Traditional Chinese Medicine in Oncology, Shanghai, P. R. China; Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
  • An HM; Department of Science & Technology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
  • Hu B; Institute of Traditional Chinese Medicine in Oncology, Shanghai, P. R. China; Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China; , beearhu@shutcm.edu.cn, Email: beearhu@hotmail.com.
Pharmazie ; 75(6): 246-249, 2020 06 01.
Article in En | MEDLINE | ID: mdl-32539919
Ursolic acid (UA) is found in multiple anticancer herbs and has shown anticancer effects in colorectal cancer (CRC) cells. The present study aimed to observe the effects of a combination of UA and oxaliplatin (Oxa), a frequently used chemotherapeutic drug in CRC, on human CRC RKO cells. The results showed that UA and Oxa synergistically inhibited the proliferation of RKO cells. A combination of UA and Oxa induced apoptosis in RKO cells and increased the activities of caspase-3, caspase-8, and caspase-9. Z-VAD-FMK, a caspase inhibitor, significantly antagonized UA- and Oxa-activated caspase-3, caspase-8, and caspase-9 and induced apoptosis. In addition, UA and Oxa downregulated the expression of X-linked inhibitor of apoptosis (XIAP) and Survivin in RKO cells. These observations suggested that a combination of UA and Oxa elicited synergistically anticancer effects in RKO cells and provided new evidence for potential application of UA and Oxa for CRC treatment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Apoptosis Limits: Humans Language: En Journal: Pharmazie Journal subject: FARMACIA Year: 2020 Document type: Article Country of publication: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Apoptosis Limits: Humans Language: En Journal: Pharmazie Journal subject: FARMACIA Year: 2020 Document type: Article Country of publication: Germany