Molecular basis of ß-arrestin coupling to formoterol-bound ß<sub>1</sub>-adrenoceptor.

Lee, Yang; Warne, Tony; Nehmé, Rony; Pandey, Shubhi; Dwivedi-Agnihotri, Hemlata; Chaturvedi, Madhu; Edwards, Patricia C; García-Nafría, Javier; Leslie, Andrew G W; Shukla, Arun K; Tate, Christopher G

Molecular basis of ß-arrestin coupling to formoterol-bound ß₁-adrenoceptor.

Lee, Yang; Warne, Tony; Nehmé, Rony; Pandey, Shubhi; Dwivedi-Agnihotri, Hemlata; Chaturvedi, Madhu; Edwards, Patricia C; García-Nafría, Javier; Leslie, Andrew G W; Shukla, Arun K; Tate, Christopher G.

Affiliation

Lee Y; MRC Laboratory of Molecular Biology, Cambridge, UK.
Warne T; MRC Laboratory of Molecular Biology, Cambridge, UK.
Nehmé R; MRC Laboratory of Molecular Biology, Cambridge, UK.
Pandey S; Creoptix AG, Wädenswil, Switzerland.
Dwivedi-Agnihotri H; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Chaturvedi M; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Edwards PC; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
García-Nafría J; MRC Laboratory of Molecular Biology, Cambridge, UK.
Leslie AGW; Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, BIFI-IQFR (CSIC), Zaragoza, Spain.
Shukla AK; Laboratorio de Microscopías Avanzadas, University of Zaragoza, Zaragoza, Spain.
Tate CG; MRC Laboratory of Molecular Biology, Cambridge, UK.

Nature ; 583(7818): 862-866, 2020 07.

Article in En | MEDLINE | ID: mdl-32555462

Subject(s)

Cryoelectron Microscopy; Formoterol Fumarate/chemistry; Formoterol Fumarate/metabolism; Receptors, Adrenergic, beta-1/chemistry; Receptors, Adrenergic, beta-1/ultrastructure; beta-Arrestin 1/chemistry; beta-Arrestin 1/ultrastructure; Amino Acid Sequence; Animals; Binding Sites; GTP-Binding Protein alpha Subunits, Gs/chemistry; GTP-Binding Protein alpha Subunits, Gs/metabolism; GTP-Binding Protein alpha Subunits, Gs/ultrastructure; HEK293 Cells; Humans; Models, Molecular; Multiprotein Complexes; Receptors, Adrenergic, beta-1/metabolism; Single-Chain Antibodies/chemistry; Single-Chain Antibodies/metabolism; Single-Chain Antibodies/ultrastructure; Zebrafish; beta-Arrestin 1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Adrenergic, beta-1 / Cryoelectron Microscopy / Formoterol Fumarate / Beta-Arrestin 1 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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