Lithium and suicide prevention in mood disorders and in the general population: A systematic review.
Neurosci Biobehav Rev
; 116: 142-153, 2020 09.
Article
in En
| MEDLINE
| ID: mdl-32561344
ABSTRACT
Suicide contributes to 1-4 % of deaths worldwide every year. We conducted a systematic review aimed at summarizing evidence on the use of lithium for the prevention of suicide risk both in mood disorders and in the general population. We followed the PRISMA methodology (keywords "lithium", "suicide" AND "suicidal" on Pubmed, Cochrane CENTRAL, Clinicaltrial.gov, other databases). Inclusion criteria lithium therapy in mood disorder or found in drinking water or scalp in the general population. Exclusion criteria no lithium administration. From 918 screened references, 18 prospective (number of participants:
153786), 10 retrospective (number ofparticipants:
61088) and 16 ecological studies (total sample 2062) were included. Most of the observational studies reported a reduction in suicide in patients with mood disorders. All studies about lithium treatment's duration reported that long-term lithium give more benefits than short-term lithium in suicide risk The evidence seems to attribute an intrinsic anti-suicidal property of lithium, independent of its proven efficacy as a mood stabilizer.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bipolar Disorder
/
Suicide Prevention
Type of study:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Neurosci Biobehav Rev
Year:
2020
Document type:
Article
Affiliation country:
Italy