In vitro and in vivo evaluation of antibacterial activity of polyhexamethylene guanidine (PHMG)-loaded TiO<sub>2</sub> nanotubes.

Wu, Fengfeng; Xu, Juntao; Yan, Ruijian; Hu, Bin; Li, Guoqi; Jin, Mingchao; Jiang, Xuesheng; Li, Jianyou; Tang, Pan; Zhu, Junkun; Yan, Shigui

In vitro and in vivo evaluation of antibacterial activity of polyhexamethylene guanidine (PHMG)-loaded TiO₂ nanotubes.

Wu, Fengfeng; Xu, Juntao; Yan, Ruijian; Hu, Bin; Li, Guoqi; Jin, Mingchao; Jiang, Xuesheng; Li, Jianyou; Tang, Pan; Zhu, Junkun; Yan, Shigui.

Affiliation

Wu F; Department of Orthopedics, the Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310009, People's Republic of China. Department of Orthopedics and Rehabilitation, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou Hospital of Zhejiang University, Huzhou 313000, People's Republic of China. These authors contributed equally to this article.

Biomed Mater ; 15(4): 045016, 2020 06 22.

Article in En | MEDLINE | ID: mdl-32567560

Subject(s)

Guanidines/chemistry; Metal Nanoparticles/chemistry; Microbial Sensitivity Tests; Nanotubes/chemistry; Titanium/chemistry; Animals; Anti-Bacterial Agents/pharmacology; Arthroplasty, Replacement; Biocompatible Materials/chemistry; Cell Adhesion/drug effects; Cell Differentiation/drug effects; Drug Delivery Systems; Femur/drug effects; In Vitro Techniques; Materials Testing; Microscopy, Electron, Scanning; Orthopedics; Osteoblasts/metabolism; Osteogenesis; Prosthesis Design; Rabbits; Staphylococcus aureus; Surface Properties; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Titanium / Microbial Sensitivity Tests / Nanotubes / Metal Nanoparticles / Guanidines Limits: Animals Language: En Journal: Biomed Mater Journal subject: ENGENHARIA BIOMEDICA Year: 2020 Document type: Article Country of publication: United kingdom

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