Nicotinamide adenine dinucleotide (NAD+): essential redox metabolite, co-substrate and an anti-cancer and anti-ageing therapeutic target.

Griffiths, Hollie B S; Williams, Courtney; King, Sarah J; Allison, Simon J

Griffiths, Hollie B S; Williams, Courtney; King, Sarah J; Allison, Simon J.

Affiliation

Griffiths HBS; School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, U.K.
Williams C; School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, U.K.
King SJ; School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, U.K.
Allison SJ; School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, U.K.

Biochem Soc Trans ; 48(3): 733-744, 2020 06 30.

Article in En | MEDLINE | ID: mdl-32573651

Subject(s)

Aging; Cytokines/metabolism; NAD/metabolism; Neoplasms/metabolism; Nicotinamide Phosphoribosyltransferase/metabolism; Oxidation-Reduction; Animals; Catalysis; Gene Expression Profiling; Glycolysis; Humans; Lactate Dehydrogenase 5/metabolism; Mitochondria/metabolism; Neoplasms/drug therapy; Poly (ADP-Ribose) Polymerase-1/metabolism; Signal Transduction; Sirtuins/metabolism; Tumor Microenvironment

Key words

NAMPT; PARP; cancer therapeutics; lactate dehydrogenase A; nicotinamide adenine dinucleotide; sirtuins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidation-Reduction / Aging / Cytokines / Nicotinamide Phosphoribosyltransferase / NAD / Neoplasms Limits: Animals / Humans Language: En Journal: Biochem Soc Trans Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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