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Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma.
Zhang, Peng-Fei; Gao, Chao; Huang, Xiao-Yong; Lu, Jia-Cheng; Guo, Xiao-Jun; Shi, Guo-Ming; Cai, Jia-Bin; Ke, Ai-Wu.
Affiliation
  • Zhang PF; Liver Cancer Institute, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Shanghai, People's Republic of China, 200032.
  • Gao C; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, People's Republic of China.
  • Huang XY; Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, 200032, P.R. China.
  • Lu JC; Liver Cancer Institute, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Shanghai, People's Republic of China, 200032.
  • Guo XJ; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, People's Republic of China.
  • Shi GM; Liver Cancer Institute, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Shanghai, People's Republic of China, 200032.
  • Cai JB; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, People's Republic of China.
  • Ke AW; Liver Cancer Institute, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Shanghai, People's Republic of China, 200032.
Mol Cancer ; 19(1): 110, 2020 06 27.
Article in En | MEDLINE | ID: mdl-32593303
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Carcinoma, Hepatocellular / Drug Resistance, Neoplasm / CCAAT-Enhancer-Binding Proteins / Ubiquitin-Protein Ligases / Exosomes / Programmed Cell Death 1 Receptor / RNA, Circular Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Mol Cancer Journal subject: NEOPLASIAS Year: 2020 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Carcinoma, Hepatocellular / Drug Resistance, Neoplasm / CCAAT-Enhancer-Binding Proteins / Ubiquitin-Protein Ligases / Exosomes / Programmed Cell Death 1 Receptor / RNA, Circular Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Mol Cancer Journal subject: NEOPLASIAS Year: 2020 Document type: Article Country of publication: United kingdom