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Recruitment of properdin by bi-specific nanobodies activates the alternative pathway of complement.
Pedersen, Dennis V; Rösner, Thies; Hansen, Annette G; Andersen, Kasper R; Thiel, Steffen; Andersen, Gregers R; Valerius, Thomas; Laursen, Nick S.
Affiliation
  • Pedersen DV; Department of Molecular Biology and Genetics, Center for Structural Biology, Aarhus University, Gustav Wieds vej 10 C, 8000 Aarhus C, Denmark.
  • Rösner T; Section for Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Christian-Albrechts-University, Rosalind-Franklin-Straße 12, 24103 Kiel, Germany.
  • Hansen AG; Department of Biomedicine, Aarhus University, Høgh-Guldbergs Gade 10, 8000 Aarhus C, Denmark.
  • Andersen KR; Department of Molecular Biology and Genetics, Center for Structural Biology, Aarhus University, Gustav Wieds vej 10 C, 8000 Aarhus C, Denmark.
  • Thiel S; Department of Biomedicine, Aarhus University, Høgh-Guldbergs Gade 10, 8000 Aarhus C, Denmark.
  • Andersen GR; Department of Molecular Biology and Genetics, Center for Structural Biology, Aarhus University, Gustav Wieds vej 10 C, 8000 Aarhus C, Denmark.
  • Valerius T; Section for Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Christian-Albrechts-University, Rosalind-Franklin-Straße 12, 24103 Kiel, Germany.
  • Laursen NS; Department of Molecular Biology and Genetics, Center for Structural Biology, Aarhus University, Gustav Wieds vej 10 C, 8000 Aarhus C, Denmark. Electronic address: nsl@mbg.au.dk.
Mol Immunol ; 124: 200-210, 2020 08.
Article in En | MEDLINE | ID: mdl-32599335
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Properdin / Antibodies, Bispecific / Complement Activation / Complement Pathway, Alternative / Single-Domain Antibodies Limits: Animals / Humans Language: En Journal: Mol Immunol Year: 2020 Document type: Article Affiliation country: Denmark
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Properdin / Antibodies, Bispecific / Complement Activation / Complement Pathway, Alternative / Single-Domain Antibodies Limits: Animals / Humans Language: En Journal: Mol Immunol Year: 2020 Document type: Article Affiliation country: Denmark