Mechanical on-off gates for regulation of drug release in cutaneous or musculoskeletal tissue repairs.
Mater Sci Eng C Mater Biol Appl
; 115: 111048, 2020 Oct.
Article
in En
| MEDLINE
| ID: mdl-32600683
ABSTRACT
Drug release synchronized with tissue motion is attractive to cutaneous or musculoskeletal tissue injury repair. Here, we have developed a method of regulating drug release by mechanical on-off gates for potential treatment of repeated injury in these tissues. The mechanical gates consisted of a multilayer structure A brittle outmost layer adhered to an elastic middle layer, which wrapped an inmost drug carrier to form the composite multilayer structure. When it was stretched, cracks appeared as mechanical gates due to mechanical performance difference between the outmost layer and the middle layer, leading to the drug release. When the external force disappeared, it recovered to stop the drug release. The controlled drug release would therefore be achieved by changing the status (opening or closure) of mechanical gates through applying this on-off mechanical stretching. A prototype based on the composite multilayer structure of adhesive coating and electrospinning technique realized the controlled release of drug and effectively repaired the incision. More types of composite multilayer structures for mechanical drug release were expected to meet curing requirement in cutaneous or musculoskeletal tissues.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Ibuprofen
/
Doxycycline
Limits:
Animals
Language:
En
Journal:
Mater Sci Eng C Mater Biol Appl
Year:
2020
Document type:
Article