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The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains.
Modi, Alessandra; Lancioni, Hovirag; Cardinali, Irene; Capodiferro, Marco R; Rambaldi Migliore, Nicola; Hussein, Abir; Strobl, Christina; Bodner, Martin; Schnaller, Lisa; Xavier, Catarina; Rizzi, Ermanno; Bonomi Ponzi, Laura; Vai, Stefania; Raveane, Alessandro; Cavadas, Bruno; Semino, Ornella; Torroni, Antonio; Olivieri, Anna; Lari, Martina; Pereira, Luisa; Parson, Walther; Caramelli, David; Achilli, Alessandro.
Affiliation
  • Modi A; Department of Biology, University of Florence, 50122, Florence, Italy.
  • Lancioni H; Department of Chemistry, Biology and Biotechnology, University of Perugia, 06123, Perugia, Italy. hovirag.lancioni@unipg.it.
  • Cardinali I; Department of Chemistry, Biology and Biotechnology, University of Perugia, 06123, Perugia, Italy.
  • Capodiferro MR; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100, Pavia, Italy.
  • Rambaldi Migliore N; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100, Pavia, Italy.
  • Hussein A; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100, Pavia, Italy.
  • Strobl C; Institute of Legal Medicine, Medical University of Innsbruck, 6020, Innsbruck, Austria.
  • Bodner M; Institute of Legal Medicine, Medical University of Innsbruck, 6020, Innsbruck, Austria.
  • Schnaller L; Institute of Legal Medicine, Medical University of Innsbruck, 6020, Innsbruck, Austria.
  • Xavier C; Institute of Legal Medicine, Medical University of Innsbruck, 6020, Innsbruck, Austria.
  • Rizzi E; Istituto di Tecnologie Biomediche, CNR, Segrate, 20090, Milan, Italy.
  • Bonomi Ponzi L; M.A.N.U. National Archeological Museum of Umbria, 06121, Perugia, Italy.
  • Vai S; Department of Biology, University of Florence, 50122, Florence, Italy.
  • Raveane A; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100, Pavia, Italy.
  • Cavadas B; IPATIMUP (Instituto de Patologia e Imunologia Molecular da Universidade do Porto), Porto, Portugal.
  • Semino O; i3S (Instituto de Investigação e Inovação em Saúde, Universidade do Porto), 4200-135, Porto, Portugal.
  • Torroni A; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100, Pavia, Italy.
  • Olivieri A; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100, Pavia, Italy.
  • Lari M; Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100, Pavia, Italy.
  • Pereira L; Department of Biology, University of Florence, 50122, Florence, Italy.
  • Parson W; IPATIMUP (Instituto de Patologia e Imunologia Molecular da Universidade do Porto), Porto, Portugal.
  • Caramelli D; i3S (Instituto de Investigação e Inovação em Saúde, Universidade do Porto), 4200-135, Porto, Portugal.
  • Achilli A; Institute of Legal Medicine, Medical University of Innsbruck, 6020, Innsbruck, Austria.
Sci Rep ; 10(1): 10700, 2020 07 01.
Article in En | MEDLINE | ID: mdl-32612271
ABSTRACT
Umbria is located in Central Italy and took the name from its ancient inhabitants, the Umbri, whose origins are still debated. Here, we investigated the mitochondrial DNA (mtDNA) variation of 545 present-day Umbrians (with 198 entire mitogenomes) and 28 pre-Roman individuals (obtaining 19 ancient mtDNAs) excavated from the necropolis of Plestia. We found a rather homogeneous distribution of western Eurasian lineages across the region, with few notable exceptions. Contemporary inhabitants of the eastern part, delimited by the Tiber River and the Apennine Mountains, manifest a peculiar mitochondrial proximity to central-eastern Europeans, mainly due to haplogroups U4 and U5a, and an overrepresentation of J (30%) similar to the pre-Roman remains, also excavated in East Umbria. Local genetic continuities are further attested to by six terminal branches (H1e1, J1c3, J2b1, U2e2a, U8b1b1 and K1a4a) shared between ancient and modern mitogenomes. Eventually, we identified multiple inputs from various population sources that likely shaped the mitochondrial gene pool of ancient Umbri over time, since early Neolithic, including gene flows with central-eastern Europe. This diachronic mtDNA portrait of Umbria fits well with the genome-wide population structure identified on the entire peninsula and with historical sources that list the Umbri among the most ancient Italic populations.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Mitochondrial / Demography / White People / Genome, Mitochondrial / Human Migration Type of study: Prognostic_studies Aspects: Determinantes_sociais_saude Limits: Humans Country/Region as subject: Europa Language: En Journal: Sci Rep Year: 2020 Document type: Article Affiliation country: Italy

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Mitochondrial / Demography / White People / Genome, Mitochondrial / Human Migration Type of study: Prognostic_studies Aspects: Determinantes_sociais_saude Limits: Humans Country/Region as subject: Europa Language: En Journal: Sci Rep Year: 2020 Document type: Article Affiliation country: Italy
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