Clinical Characteristics, Histopathology, and Tissue Immunolocalization of Chikungunya Virus Antigen in Fatal Cases.
Clin Infect Dis
; 73(2): e345-e354, 2021 07 15.
Article
in En
| MEDLINE
| ID: mdl-32615591
ABSTRACT
BACKGROUND:
Death in patients with chikungunya is rare and has been associated with encephalitis, hemorrhage, and septic shock. We describe clinical, histologic, and immunohistochemical findings in individuals who died following chikungunya virus (CHIKV) infection.METHODS:
We identified individuals who died in Puerto Rico during 2014 following an acute illness and had CHIKV RNA detected by reverse transcriptase-polymerase chain reaction in a pre- or postmortem blood or tissue specimen. We performed histopathology and immunohistochemistry (IHC) for CHIKV antigen on tissue specimens and collected medical data via record review and family interviews.RESULTS:
Thirty CHIKV-infected fatal cases were identified (0.8/100 000 population). The median age was 61 years (range 6 days-86 years), and 19 (63%) were male. Death occurred a median of 4 days (range 1-29) after illness onset. Nearly all (93%) had at least 1 comorbidity, most frequently hypertension, diabetes, or obesity. Nine had severe comorbidities (eg, chronic heart or kidney disease, sickle cell anemia) or coinfection (eg, leptospirosis). Among 24 fatal cases with tissue specimens, 11 (46%) were positive by IHC. CHIKV antigen was most frequently detected in mesenchymal tissues and mononuclear cells including tissue macrophages, blood mononuclear cells, splenic follicular dendritic cells, and Kupffer cells. Common histopathologic findings were intra-alveolar hemorrhage and edema in the lung, chronic or acute tenosynovitis, and increased immunoblasts in the spleen. CHIKV infection likely caused fatal septic shock in 2 patients.CONCLUSIONS:
Evaluation of tissue specimens provided insights into the pathogenesis of CHIKV, which may rarely result in septic shock and other severe manifestations.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chikungunya virus
/
Diabetes Mellitus
/
Chikungunya Fever
Type of study:
Prognostic_studies
Limits:
Humans
/
Male
/
Middle aged
Country/Region as subject:
Caribe
/
Puerto rico
Language:
En
Journal:
Clin Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2021
Document type:
Article
Affiliation country:
United States