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Antifungal susceptibility of oral isolates of Candida species from chronic kidney disease patients on chronic dialysis.
de la Rosa-García, E; Olalde-Hernández, M J; Irigoyen-Camacho, M E; Mondragón-Padilla, A; Mendoza-Juache, A; Sánchez-Vargas, L O.
Affiliation
  • de la Rosa-García E; Department of Health Care, Autonomous Metropolitan University-Xochimilco, México City, Mexico.
  • Olalde-Hernández MJ; Department of Health Care, Autonomous Metropolitan University-Xochimilco, México City, Mexico.
  • Irigoyen-Camacho ME; Department of Health Care, Autonomous Metropolitan University-Xochimilco, México City, Mexico.
  • Mondragón-Padilla A; Simplified Surgery Specialty Clinic "Dr. Pedro Barcenas Hiriart", Institute of Social Security and Services of State Workers (ISSSTE), San Luis Potosí, Mexico.
  • Mendoza-Juache A; Biochemistry and Microbiology laboratory, Faculty of Stomatology - University Autonomous of San Luis Potosí, San Luis Potosí, Mexico.
  • Sánchez-Vargas LO; Biochemistry and Microbiology laboratory, Faculty of Stomatology - University Autonomous of San Luis Potosí, San Luis Potosí, Mexico. Electronic address: lo.sanchezvargas@gmail.com.
J Mycol Med ; 30(3): 101009, 2020 Sep.
Article in En | MEDLINE | ID: mdl-32620497
Chronic renal disease patients under chronic dialysis (CRDD) have a multifactorial immunological deterioration with an increased risk of Candida infections. Incidence of Candida infections is increasing. Choice of suitable antifungal agents is limited due to the resistance of some species to several antifungals. Aim of the present study was to identify the distribution and antifungal susceptibility patterns of oral isolated Candida species from infected and colonized patients, as well as to investigate the risk factors for oral infection in patients on dialysis. Cross-sectional study, approved by the institutional bioethics committees was performed in CRDD patients. Demographic, clinic data, and oral mucosa samples were obtained. Infection diagnosis was established clinically and confirmed with exfoliative cytology, each sample was plated on CHROMagar Candida and incubated at 36°C for 2 days. Yeast species were identified by carbohydrate assimilation ID 32C AUX system and the apiweb database. For the antifungal susceptibility test, the M44 A-3 method (CLSI) using fluconazole (FCZ), miconazole (MCZ), nystatin (NYS), and voriconazole (VCZ). Study included 119 participants, the main cause of CRD was nephropathy due to DM2 (58%), and three-fourths of the patients were under hemodialysis. Candida prevalence was 56.3% of 67 colonized or infected patients, 88 isolates were obtained. Principal identified species were C. albicans (51.1%), C. glabrata (25%), and C. tropicalis (14.8%). C. glabrata showed a reduced response to FCZ in 50% of isolates and C. albicans had a reduced response in 16% of the isolates. Antifungal agent with the least efficacious response or with the lowest susceptibility in the isolates of these patients was MCZ, followed by VCZ and FCZ, whereas NYS induced the best antifungal response.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Candida / Candidiasis, Oral / Renal Insufficiency, Chronic / Mouth / Antifungal Agents Type of study: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspects: Ethics Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Mexico Language: En Journal: J Mycol Med Year: 2020 Document type: Article Affiliation country: Mexico Country of publication: France

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Candida / Candidiasis, Oral / Renal Insufficiency, Chronic / Mouth / Antifungal Agents Type of study: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspects: Ethics Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Mexico Language: En Journal: J Mycol Med Year: 2020 Document type: Article Affiliation country: Mexico Country of publication: France