Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders.
Open Biol
; 10(7): 200063, 2020 07.
Article
in En
| MEDLINE
| ID: mdl-32634371
ABSTRACT
The gut microbiome regulates a relationship with the brain known as the gut-microbiota-brain (GMB) axis. This interaction is influenced by immune cells, microbial metabolites and neurotransmitters. Recent findings show gut dysbiosis is prevalent in autism spectrum disorder (ASD) as well as attention deficit hyperactivity disorder (ADHD). There are previously established negative correlations among vitamin D, vitamin D receptor (VDR) levels and severity of ASD as well as ADHD. Both vitamin D and VDR are known to regulate homeostasis in the brain and the intestinal microbiome. This review summarizes the growing relationship between vitamin D/VDR signalling and the GMB axis in ASD and ADHD. We focus on current publications and summarize the progress of GMB in neurodevelopmental disorders, describe effects and mechanisms of vitamin D/VDR in regulating the microbiome and synoptically highlight the potential applications of targeting vitamin D/VDR signalling in neurodevelopment disorders.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Attention Deficit Disorder with Hyperactivity
/
Vitamin D
/
Receptors, Calcitriol
/
Autism Spectrum Disorder
Limits:
Humans
Language:
En
Journal:
Open Biol
Year:
2020
Document type:
Article
Affiliation country:
United States