Unexpected Synergy: Macrophages and Schwann Cells Modulate Pathology in a Newborn Disease through a Shared Substrate.
Neuron
; 107(1): 1-3, 2020 07 08.
Article
in En
| MEDLINE
| ID: mdl-32645303
ABSTRACT
Krabbe disease is characterized by GALC deficiency and Schwann cell impairment. In a recent issue of Neuron, Weinstock et al. (2020) show that hematopoietic stem cell transplantation, an established therapy, improves pathology in a mouse model through an unexpected GALC-dependent mechanism, i.e., by providing functional macrophages capable of phagocytosis, rather than by supplying GALC for Schwann cell function.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukodystrophy, Globoid Cell
Limits:
Animals
/
Humans
/
Newborn
Language:
En
Journal:
Neuron
Journal subject:
NEUROLOGIA
Year:
2020
Document type:
Article
Affiliation country:
United States