The Nose-To-Brain Transport of Polymeric Nanoparticles Is Mediated by Immune Sentinels and Not by Olfactory Sensory Neurons.

Kumarasamy, Murali; Sosnik, Alejandro

Kumarasamy, Murali; Sosnik, Alejandro.

Affiliation

Kumarasamy M; Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
Sosnik A; Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.

Adv Biosyst ; 3(12): e1900123, 2019 12.

Article in En | MEDLINE | ID: mdl-32648679

Subject(s)

Nanoparticles/metabolism; Olfactory Mucosa; Polymers/pharmacokinetics; Prosencephalon; Animals; Cells, Cultured; Fluorescent Dyes/chemistry; Fluorescent Dyes/pharmacokinetics; Microglia/cytology; Microglia/immunology; Microglia/metabolism; Nanoparticles/chemistry; Neurons/cytology; Neurons/immunology; Neurons/metabolism; Olfactory Mucosa/cytology; Olfactory Mucosa/immunology; Olfactory Mucosa/metabolism; Particle Size; Polymers/chemistry; Prosencephalon/cytology; Prosencephalon/immunology; Prosencephalon/metabolism; Rats

Key words

cortical neurons; microglia; nose-to-brain transport; olfactory sensory neurons; polymeric nanoparticles

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymers / Olfactory Mucosa / Prosencephalon / Nanoparticles Type of study: Prognostic_studies Limits: Animals Language: En Journal: Adv Biosyst Year: 2019 Document type: Article Affiliation country: Israel Country of publication: Germany

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