Objectively measured physical activity is associated with dorsolateral prefrontal cortex volume in older adults.
Neuroimage
; 221: 117150, 2020 11 01.
Article
in En
| MEDLINE
| ID: mdl-32668298
ABSTRACT
BACKGROUND:
Epidemiological studies suggest physical activity (PA) can slow or prevent both cognitive decline and age-related atrophy in frontal and hippocampal gray matter volumes. However, much of this evidence is based on self-reported measures of PA.METHODS:
PA was measured objectively with a SenseWear™ Armband to examine the cross-sectional associations between the duration of light, moderate and vigorous intensity PA with gray matter volume in the dorsolateral prefrontal cortex (DLPFC) and hippocampus in 167 (female 43%) cognitively healthy older adults aged 73 to 78.RESULTS:
The duration of objective moderate to vigorous intensity physical activity (MVPA) was associated with a greater volume of the right DLPFC (ß â= â0.16; p â= â0.04). In addition, objective moderate-intensity PA alone was also associated with greater volume of the left (ß â= â0.17; p â= â0.03) and right (ß â= â0.19; p â= â0.01) DLPFC after controlling for covariates and adjustment for multiple comparisons. In contrast, there were no significant associations between light- or vigorous-intensity PA and gray matter volumes (all p â> â0.05). No associations between PA and cognitive performance were detected, and self-reported PA was not associated with any of the outcomes investigated.CONCLUSIONS:
These findings suggest that an intensity-dependent relationship may exist, whereby a greater duration of MVPA, perhaps driven by moderate-intensity PA, is associated with preserved gray matter volume in frontal regions of the brain. Future research should investigate the mechanisms of this dose-effect and determine whether greater brain volumes associated with objective PA convey protective effects against cognitive decline.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Psychomotor Performance
/
Aging
/
Exercise
/
Prefrontal Cortex
/
Executive Function
/
Gray Matter
/
Hippocampus
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Neuroimage
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2020
Document type:
Article