Merkel Cell Polyomavirus Small Tumor Antigen Activates Matrix Metallopeptidase-9 Gene Expression for Cell Migration and Invasion.

Nwogu, Nnenna; Ortiz, Luz E; Whitehouse, Adrian; Kwun, Hyun Jin

Nwogu, Nnenna; Ortiz, Luz E; Whitehouse, Adrian; Kwun, Hyun Jin.

Affiliation

Nwogu N; Department of Microbiology and Immunology, Penn State University College of Medicine, Hershey, Pennsylvania, USA.
Ortiz LE; Penn State Cancer Institute, Hershey, Pennsylvania, USA.
Whitehouse A; Department of Microbiology and Immunology, Penn State University College of Medicine, Hershey, Pennsylvania, USA.
Kwun HJ; Penn State Cancer Institute, Hershey, Pennsylvania, USA.

J Virol ; 94(19)2020 09 15.

Article in En | MEDLINE | ID: mdl-32669331

Subject(s)

Antigens, Neoplasm/genetics; Antigens, Neoplasm/metabolism; Cell Movement/genetics; Cell Movement/physiology; Matrix Metalloproteinase 9/genetics; Matrix Metalloproteinase 9/metabolism; Merkel cell polyomavirus/metabolism; ADAM10 Protein/genetics; ADAM10 Protein/metabolism; Animals; Antigens, Viral, Tumor; COS Cells; Carcinoma, Merkel Cell/virology; Cell Proliferation; Cell Transformation, Neoplastic; Chlorocebus aethiops; Epithelial-Mesenchymal Transition/genetics; Gene Expression; HEK293 Cells; Humans; Oncogene Proteins; Polyomavirus Infections/metabolism; Skin Neoplasms/virology; Snails; Tumor Virus Infections/virology; Ubiquitin-Protein Ligases/metabolism

Key words

FBW7; Merkel cell carcinoma; Merkel cell polyomavirus; cell invasion; cell migration; matrix metallopeptidase-9; small tumor antigen

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Movement / Matrix Metalloproteinase 9 / Merkel cell polyomavirus / Antigens, Neoplasm Limits: Animals / Humans Language: En Journal: J Virol Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States

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