Effects of age and sex on the relationship between body fat area and kidney events in patients with chronic kidney disease.

ABSTRACT

We examined the effects of age and sex on the relationship between body fat area and kidney events. We included 367 chronic kidney disease patients between 2011 and 2017. Patients' median age was 73.0 years; 262 (71.4%) patients were male. The median estimated glomerular filtration rate was 20.2 mL/min/1.73 m2 . During the observation period, 187 patients developed kidney events. In males aged <75 years, high subcutaneous fat area was a risk factor for kidney events (hazard ratio 1.06, 95% CI 1.02-1.11). In females aged <75 years, high visceral fat area reduced kidney events (hazard ratio 0.83, 95% CI 0.71-0.97). In males and females ≥75 years, visceral fat area and subcutaneous fat area were not associated with kidney events. Body fat area was not a risk factor for chronic kidney disease progression in elderly patients. Opposite effects, in sex-related body fat and kidney events, were shown in young patients.