Immunogenicity of Immunotoxins Containing <i>Pseudomonas</i> Exotoxin A: Causes, Consequences, and Mitigation.

Mazor, Ronit; Pastan, Ira

Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation.

Mazor, Ronit; Pastan, Ira.

Affiliation

Mazor R; Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Pastan I; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Front Immunol ; 11: 1261, 2020.

Article in En | MEDLINE | ID: mdl-32695104

Subject(s)

Exotoxins/immunology; Immunotoxins/immunology; Pseudomonas/immunology; ADP Ribose Transferases/immunology; Animals; Antibody Formation/immunology; Bacterial Toxins/immunology; Clinical Trials as Topic; Epitopes, B-Lymphocyte/immunology; Exotoxins/chemistry; Exotoxins/pharmacokinetics; Humans; Immunoassay; Immunomodulation/drug effects; Immunotoxins/chemistry; Immunotoxins/pharmacokinetics; Mesothelin; Neoplasms/drug therapy; Recombinant Proteins/immunology; Structure-Activity Relationship; Treatment Outcome; Virulence Factors/immunology; Pseudomonas aeruginosa Exotoxin A

Key words

B cell epitopes; LMB-100; T cell epitopes; anti-drug antibodies (ADA); moxetumomab pasudotox; neutralizing antibodies; recombinant immunotoxins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas / Immunotoxins / Exotoxins Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Front Immunol Year: 2020 Document type: Article Affiliation country: United States Country of publication: Switzerland

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