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Telomerase and telomeres in aging theory and chronographic aging theory (Review).
Razgonova, Mayya P; Zakharenko, Alexander M; Golokhvast, Kirill S; Thanasoula, Maria; Sarandi, Evangelia; Nikolouzakis, Konstantinos; Fragkiadaki, Persefoni; Tsoukalas, Dimitris; Spandidos, Demetrios A; Tsatsakis, Aristidis.
Affiliation
  • Razgonova MP; N.I. Vavilov All­Russian Institute of Plant Genetic Resources, 190000 Saint­Petersburg, Russia.
  • Zakharenko AM; N.I. Vavilov All­Russian Institute of Plant Genetic Resources, 190000 Saint­Petersburg, Russia.
  • Golokhvast KS; N.I. Vavilov All­Russian Institute of Plant Genetic Resources, 190000 Saint­Petersburg, Russia.
  • Thanasoula M; Metabolomic Μedicine, Health Clinics for Autoimmune and Chronic Diseases, 10674 Athens, Greece.
  • Sarandi E; Metabolomic Μedicine, Health Clinics for Autoimmune and Chronic Diseases, 10674 Athens, Greece.
  • Nikolouzakis K; Laboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece.
  • Fragkiadaki P; Laboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece.
  • Tsoukalas D; Metabolomic Μedicine, Health Clinics for Autoimmune and Chronic Diseases, 10674 Athens, Greece.
  • Spandidos DA; Laboratory of Clinical Virology, School of Medicine, University of Crete, Heraklion 71003, Greece.
  • Tsatsakis A; Laboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece.
Mol Med Rep ; 22(3): 1679-1694, 2020 09.
Article in En | MEDLINE | ID: mdl-32705188
The current review focuses on the connection of telomerase and telomeres with aging. In this review, we describe the changes in telomerase and telomere length (TEL) during development, their role in carcinogenesis processes, and the consequences of reduced telomerase activity. More specifically, the connection of TEL in peripheral blood cells with the development of aging­associated diseases is discussed. The review provides systematic data on the role of telomerase in mitochondria, the biology of telomeres in stem cells, as well as the consequences of the forced expression of telomerase (telomerization) in human cells. Additionally, it presents the effects of chronic stress exposure on telomerase activity, the effect of TEL on fertility, and the effect of nutraceutical supplements on TEL. Finally, a comparative review of the chronographic theory of aging, presented by Olovnikov is provided based on currently available scientific research on telomere, telomerase activity, and the nature of aging by multicellular organisms.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Telomere / Telomerase Limits: Humans Language: En Journal: Mol Med Rep Year: 2020 Document type: Article Affiliation country: Russia Country of publication: Greece

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Telomere / Telomerase Limits: Humans Language: En Journal: Mol Med Rep Year: 2020 Document type: Article Affiliation country: Russia Country of publication: Greece