Telomerase and telomeres in aging theory and chronographic aging theory (Review).
Mol Med Rep
; 22(3): 1679-1694, 2020 09.
Article
in En
| MEDLINE
| ID: mdl-32705188
The current review focuses on the connection of telomerase and telomeres with aging. In this review, we describe the changes in telomerase and telomere length (TEL) during development, their role in carcinogenesis processes, and the consequences of reduced telomerase activity. More specifically, the connection of TEL in peripheral blood cells with the development of agingassociated diseases is discussed. The review provides systematic data on the role of telomerase in mitochondria, the biology of telomeres in stem cells, as well as the consequences of the forced expression of telomerase (telomerization) in human cells. Additionally, it presents the effects of chronic stress exposure on telomerase activity, the effect of TEL on fertility, and the effect of nutraceutical supplements on TEL. Finally, a comparative review of the chronographic theory of aging, presented by Olovnikov is provided based on currently available scientific research on telomere, telomerase activity, and the nature of aging by multicellular organisms.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Telomere
/
Telomerase
Limits:
Humans
Language:
En
Journal:
Mol Med Rep
Year:
2020
Document type:
Article
Affiliation country:
Russia
Country of publication:
Greece