Your browser doesn't support javascript.
loading
Retardation of some drugs in thin-layer chromatographic systems with impregnated silica gel plates with hen's egg white and bovine serum albumin.
Jaglinska, Kamila; Polak, Beata; Klimek-Turek, Anna; Pomastowski, Pawel; Buszewski, Boguslaw; Dzido, Tadeusz H.
Affiliation
  • Jaglinska K; Physical Chemistry Department. Medical University of Lublin, 4A Chodzki Street, 20-093 Lublin, Poland. Electronic address: kamila.jaglinska@umlub.pl.
  • Polak B; Physical Chemistry Department. Medical University of Lublin, 4A Chodzki Street, 20-093 Lublin, Poland.
  • Klimek-Turek A; Physical Chemistry Department. Medical University of Lublin, 4A Chodzki Street, 20-093 Lublin, Poland.
  • Pomastowski P; Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland; Centre for Modern Interdisciplinary Technologies. Nicolaus Copernicus University in Torun, 4 Wilenska Street, 87-100 Torun, Poland.
  • Buszewski B; Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland; Centre for Modern Interdisciplinary Technologies. Nicolaus Copernicus University in Torun, 4 Wilenska Street, 87-100 Torun, Poland.
  • Dzido TH; Physical Chemistry Department. Medical University of Lublin, 4A Chodzki Street, 20-093 Lublin, Poland.
J Chromatogr A ; 1625: 461277, 2020 Aug 16.
Article in En | MEDLINE | ID: mdl-32709329
The influence of impregnation the chromatographic plate adsorbent layer, silica, with hen's egg white albumin (OVA) or bovine serum albumin (BSA) on the retention of some popular medicines (paracetamol, aminophenazone, theophylline, caffeine, acetanilide, ciprofloxacin, tramadol, acetylsalicylic acid, acebutolol) is investigated. The effect of composition and buffer pH of the mobile phase on solute separation selectivity is also studied. The chromatographic systems with and without above mentioned albumins and their influence on investigated drug retention are compared. In general, it has been turned out that retention of tested medicines in systems with the sorbent impregnated with albumin significantly increase relative to those with non-impregnated.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serum Albumin, Bovine / Pharmaceutical Preparations / Chromatography, Thin Layer / Egg White / Silica Gel Limits: Animals Language: En Journal: J Chromatogr A Year: 2020 Document type: Article Country of publication: Netherlands
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serum Albumin, Bovine / Pharmaceutical Preparations / Chromatography, Thin Layer / Egg White / Silica Gel Limits: Animals Language: En Journal: J Chromatogr A Year: 2020 Document type: Article Country of publication: Netherlands