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Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test.
Kalyatanda, Gautam; Rand, Kenneth; Lindner, Martin S; Hong, David K; Sait Albayram, Mehmet; Gregory, Jason; Kresak, Jesse; Ibne, Karim M Ali; Cope, Jennifer R; Roy, Shantanu; Gary, Joy M; Reddy, Varalakshmi; Ahmed, Asim A.
Affiliation
  • Kalyatanda G; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
  • Rand K; Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
  • Lindner MS; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
  • Hong DK; Karius, Inc., Redwood City, California, USA.
  • Sait Albayram M; Karius, Inc., Redwood City, California, USA.
  • Gregory J; Department of Radiology, University of Florida College of Medicine, Gainesville, Florida, USA.
  • Kresak J; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
  • Ibne KMA; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
  • Cope JR; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Roy S; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Gary JM; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Reddy V; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Ahmed AA; Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA.
Open Forum Infect Dis ; 7(7): ofaa189, 2020 Jul.
Article in En | MEDLINE | ID: mdl-32715017
ABSTRACT
Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: Open Forum Infect Dis Year: 2020 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: Open Forum Infect Dis Year: 2020 Document type: Article Affiliation country: United States