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An Overview of the Mechanisms of Marine Fungi-Derived Anti-Inflammatory and Anti-Tumor Agents and their Novel Role in Drug Targeting.
Shams Ul Hassan, Syed; Ishaq, Muhammad; Zhang, Wei-Dong; Jin, Hui-Zi.
Affiliation
  • Shams Ul Hassan S; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
  • Ishaq M; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
  • Zhang WD; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
  • Jin HZ; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
Curr Pharm Des ; 27(22): 2605-2614, 2021.
Article in En | MEDLINE | ID: mdl-32723250
ABSTRACT
Marine fungi with their successful pharmacological effects were considered to be the treasure of ocean medicines concerning the striking ability of their secondary metabolites. Literature over literature has been published on fungi derived bioactive molecules to probe its therapeutic potential. Marine fungi have an implicit to cede future medicines against life-threatening diseases, such as cancer and several emerging inflammations. The biological actions of many marine fungi-derived secondary metabolites are still unlocked, for an assorted number of bioactive compounds by which they interact with human diseases are discussed here with comprehensive diagrams. This knowledge is one of the main tracks to be established specifically for the successful transformation of bioactive compounds to medicines. Marine fungi produce a diverse range of biochemical substances with precious carbon scaffolds, which are the main component interplaying with human diseases at distinctive spots. Specific diseases having a flair to fight at distinctive targets within the body can lead to a new trend of raising the chances of developing targeted drugs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Curr Pharm Des Journal subject: FARMACIA Year: 2021 Document type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Curr Pharm Des Journal subject: FARMACIA Year: 2021 Document type: Article Affiliation country: China