The Physiological Importance of Bile Acid Structure and Composition on Glucose Homeostasis.
Curr Diab Rep
; 20(9): 42, 2020 07 28.
Article
in En
| MEDLINE
| ID: mdl-32725339
ABSTRACT
PURPOSE OF REVIEW Studies have identified several effects of bile acids (BAs) in glucose homeostasis, energy expenditure, and body weight control, through receptor-dependent and independent mechanisms. BAs are produced from cholesterol and characterized by their structures, which result from enzymes in the liver and the gut microbiota. The aim of this review is to characterize the effects of BA structure and composition on diabetes. RECENT FINDINGS:
The hydroxyl groups of BAs interact with binding pockets of receptors and enzymes that affect glucose homeostasis. Human and animal studies show that BA composition is associated with insulin resistance and food intake regulation. The hydroxylation of BAs and BA composition contributes to glucose regulation. Modulation of BA composition has the potential to improve glucose metabolism.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin Resistance
/
Gastrointestinal Microbiome
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Diab Rep
Journal subject:
ENDOCRINOLOGIA
Year:
2020
Document type:
Article
Affiliation country:
United States