Reprogrammable fluorescence logic sensing for biomolecules via RNA-like coenzyme A-based coordination polymer.

In this study, coenzyme A (CoA)-based coordination polymers (CPs) have been generated in situ by exploiting the reaction of thiols with metal ion (Au(III) or Ag(I)), which are dependent on both thiol-metal and aurophilic metal∙metal interaction. It is interesting to note that CPs-related biosensing capabilities toward some biomolecules including ascorbic acid (AA), cysteine (Cys) and glutathione (GSH) are also investigated via SYBR Green II (SGII)-derived fluorescence switchable mechanisms. The synthesized CPs display especial RNA-like structure and are capable of initiating the fluorescence of SGII. Conversely, AA, Cys or GSH can give rise to the structural destruction of RNA-like CPs, thus inhibiting the fluorescence signal, and quantitative detection of these biomolecules are achieved favorably with a detection limit of 7.2, 0.55 and 0.48 nM, respectively. Meanwhile, the fascinating fluorescence on-off property and simple synthetic process are employed to build a series of basic logic gates (YES, NOT, OR, AND, INHIBIT and NOR) and multiple configurable logic gates (OR-AND and OR-OR-INHIBIT) along with different logic inputs. In view of these, developing CoA-based CPs as a new material to execute logic operations provides a valuable platform to establish the next generation of advanced molecular devices for clinic diagnostic and biomedical research.