The hepatocyte clock and feeding control chronophysiology of multiple liver cell types.
Science
; 369(6509): 1388-1394, 2020 09 11.
Article
in En
| MEDLINE
| ID: mdl-32732282
ABSTRACT
Most cells of the body contain molecular clocks, but the requirement of peripheral clocks for rhythmicity and their effects on physiology are not well understood. We show that deletion of core clock components REV-ERBα and REV-ERBß in adult mouse hepatocytes disrupts diurnal rhythms of a subset of liver genes and alters the diurnal rhythm of de novo lipogenesis. Liver function is also influenced by nonhepatocytic cells, and the loss of hepatocyte REV-ERBs remodels the rhythmic transcriptomes and metabolomes of multiple cell types within the liver. Finally, alteration of food availability demonstrates the hierarchy of the cell-intrinsic hepatocyte clock mechanism and the feeding environment. Together, these studies reveal previously unsuspected roles of the hepatocyte clock in the physiological coordination of nutritional signals and cell-cell communication controlling rhythmic metabolism.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation
/
Circadian Rhythm
/
Hepatocytes
/
Feeding Behavior
/
Circadian Clocks
/
Liver
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Science
Year:
2020
Document type:
Article
Affiliation country:
United States